一般財団法人 医薬品医療機器
レギュラトリーサイエンス財団 医薬標準品センター

The effect of silicon-based agent on allergic bronchitis caused by ragweed pollen: Takeuchi H, Takashima S, Taya M, Hino N, Kakinuma C, Kobayashi Y, Kobayashi H, Nakagawa S. European Review for Medical and Pharmacological Sciences, 29(12):578-586(2025); DOI: 10.26355/eurrev_202512_37567

Room-temperature X-ray data collection enabled the structural determination of statin-bound CYP105A1: Takita T, Yoneda S , Yasuda K, Mizutani K, Yasukawa K, Sakaki T, Mikami B. Acta Crystallographica Section D, 81(10), 573–583 (2025); DOI: 10.1107/S2059798325007673

Cooperative inhibition in cytochrome P450 between a substrate and an apparent noncompetitive inhibitor: Hirano Y, Yoneda S , Yasuda K, Kurita N, Kawagoe F, Mikami B, Takita T, Yasukawa K, Ikushiro S, Takimoto-Kamimura M, Kittaka A, Sakaki T, Tamada T. Journal of Biological Chemistry, 301(6), 108513 (2025); DOI: 10.1016/j.jbc.2025.108513

Metabolism of simvastatin by Streptomyces griseolus CYP105A1 and its variants for the production of human simvastatin metabolites: Yoneda S, Yasuda K, Mikami B, Takita T, Yasukawa K, Hamada M, Imaishi H, Sakaki T, Ikushiro S. Drug Metabolism and Pharmacokinetics, 65, 101506 (2025); DOI: 10.1016/j.dmpk.2025.101506

Absolute purity determination of an organic fluorine pharmaceutical voriconazole via quantitative ¹⁹F-NMR and method validation: Nahoko Uchiyama, Junko Hosoe, Kohei Kiyota, Takanori Komatsu, Naoki Sugimoto, Kyoko Ishizuki, Tatsuo Koide, Mika Murabayashi, Taeko Shinozaki, Yoshinori Fujimine, Katsuya Ofuji, Hitoshi Shimizu, Kazuhiro Fujita, Takashi Hasebe, Yumi Asai, Eri Ena, Yoshinobu Makino, Toru Miura, Yasuhiro Muto, Katsuo Asakura, Takako Suematsu, Hitomi Abe, Ai Kohama, Takashi Goto, Masu Yasuda, Tomohiko Ueda, Yukihiro Goda. Journal of Pharmaceutical and Biomedical Analysis Open Volume 4, December 2024, 100039

Quantitative ³¹P-NMR for the Purity Determination of the Organophosphorus Compound Brigatinib and Its Method Validation: Uchiyama N, Hosoe J, Komatsu T, Sugimoto N, Ishizuki K, Koide T, Murabayashi M, Shinozaki T, Kobayashi K, Fujimine Y, Ofuji K, Shimizu H, Hasebe T, Asai Y, Ena E, Kiyota K, Fujita K, Makino Y, Miura T, Muto Y, Asakura K, Suematsu T, Muto H, Kohama A, Goto T, Yasuda M, Ueda T, Goda Y. Chem Pharm Bull, 72, 36-40 (2024)

Quality Evaluation of Gentamicin Sulfate Reference Standards in Japanese Pharmacopoeia Using Hydrophilic Interaction Chromatography Combined With Tandem Mass Spectrometry: Maekawa K, Sawa R, Matsui M, Konda T, Kubota Y, Matsuo A, Maeda A, Takahashi C, Tanimoto T, Nakagawa Y, Yoneda S, Mori Y, Susuki S. Journal of AOAC INTERNATIONAL, 107, 234-241 (2024)

Collaborative Study of Bacterial Endotoxins Test Using Recombinant Factor C-Based Procedure for Detection of Lipopolysaccharides (Part 3): Kikuchi Y, Muroi M, Nakagawa Y, Ebisawa A, Hayashi M, Takeuchi H, Kiwamoto Y, Matsumura K, Yoshimoto R, Tsuzuki N, Oikawa N, Hashimoto M, Hiramatsu Y, Fukami M, Kobayashi K, Sanda N, Eto S, Mori M, Martinez O, Suzuki M, Sekiguchi S, Ouchi K, Fukuchi H, Kitagawa T, Kizawa M, Masuda T, Oda T, Mizumura H, Ogura N, Iida D, Sueoka K, Tanno Y, Tsuchiya M．医薬品医療機器レギュラトリーサイエンス，54(4) 341-351 (2023)

日局医薬品各条合成グルカゴンの定量法等に関する研究：橋井則貴，蛭田葉子，林 真由美，海老澤亜樹子，中川ゆかり，石井明子．医薬品医療機器レギュラトリーサイエンス，54(5) 428-438 (2023)

取扱い環境により容易に転移するチアミン塩化物塩酸塩の擬似結晶多形の識別手法：山田彩乃，村尾 渚，佐藤明啓，藤本雄三，中川ゆかり，谷本 剛．YAKUGAKU ZASSHI，142 295-302 （2022）

Quantitative ³¹P-NMR for Purity Determination of Sofosbuvir and Method Validation: Uchiyama N, Kiyota K, Hosoe J, Komatsu T, Sugimoto N, Ishizuki K, Koide T, Murabayashi M, Kobayashi K, Fujimine Y, Yokose T, Ofuji K, Shimizu H, Hasebe T, Asai Y, Ena E, Kikuchi J, Fujita K, Makino Y, Iwamoto Y, Miura T, Muto Y, Asakura K, Suematsu T, Muto H, Kohama A, Goto T, Yasuda M, Ueda T, Goda Y. Chem Pharm Bull, 70, 892-900 (2022)

Purity Determination of Cyclophosphamide Hydrate by Quantitative ³¹P-NMR and Method Validation: Uchiyama N, Hosoe J, Sugimoto N, Ishizuki K, Koide T, Murabayashi M, Miyashita N, Kobayashi K, Fujimine Y, Yokose T, Ofuji K, Shimizu H, Hasebe T, Asai Y, Ena E, Kikuchi J, Kiyota K, Fujita K, Makino Y, Yasobu N, Iwamoto Y, Miura T, Mizui K, Asakura K, Suematsu T, Muto H, Kohama A, Goto T, Yasuda M, Ueda T, Goda Y. Chem Pharm Bull, 69, 630-638 (2021)

Absolute purity determination of a hygroscopic substance, indocyanine green, using quantitative NMR (qNMR): Uchiyama N, Hosoe J, Sugimoto N, Ishizuki K, Koide T, Murabayashi M, Miyashita N, Kobayashi K, Fujimine Y, Yokose T, Ofuji K, Shimizu H, Hasebe T, Asai Y, Ena E, Kikuchi J, Kiyota K, Fujita K, Makino Y, Yasobu N, Yamada Y, Iwamoto Y, Miura T, Mizui K, Asakura K, Suematsu T, Kohama A, Goda Y. Chem Pharm Bull, 69, 118-123 (2021)